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4 Discussion UA is the end product of endogenous purine metabolism

(2) Advantages Over Synthetics : Natural agonists often exhibit fewer gastrointestinal side effects and additional benefits (e.g., anti-inflammatory, lipid-lowering), though their efficacy and half-life are inferior to drugs like semaglutide

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Additionally, low level (10 M) H 2 O 2 treatment induced JNK-mediated FOXO3a translocation and activation to promote AKT-mediated stem cell proliferation, which when transplanted, increased re-epithelialisation and angiogenesis in wounded mice 147

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